It takes one to know one—a community that is. With that in mind, a community of pioneering scientists from MSU’s College of Natural Science and the University of California, Los Angeles, came together to design a multifaceted approach to investigating one of the most complex and abundant communities on Earth—microbiomes. The first-of-its-kind ecological investigation into the complexity of gut microbiological communities is funded by the NSF and will provide new insights into microbial community interaction from mechanistic models and network theory and lead the way for numerous applications in health and human and natural systems.