On Oct. 4 and 5, 2019, Michigan State University is hosting a Molecular Biophysics Symposium in honor of the grand opening of the MSU Cryo-EM Core Facility on campus. In addition to unveiling the new Cryo-EM microscope, the symposium will highlight cutting-edge research in molecular biophysics, which will benefit from this new technology. Cryo-electron microscopy is becoming mainstream for studying molecular details such as the architecture of cells, viruses as well as nucleic acids, small molecules, and protein assemblies. Recent developments in microscope design and imaging hardware, automation, and advances in camera technology have greatly advanced the effectiveness of cryo-EM methods. We are now living in an era of the “Cryo-EM resolution revolution.” The facility is equipped with a Thermo Scientific™ Talos™ Arctica, which is a 200kV FEG transmission electron microscope used for delivering high-resolution 3D characterization of biological samples. Cryo-EM can be used for a number of interdisciplinary types of research—it’s important to chemists, to biologists, to microbiologists and to students conducting research in these areas. Having a microscope of this caliber puts MSU in an elite group and enables important advances in research.